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Fig. 6 | Retrovirology

Fig. 6

From: Trim28 acts as restriction factor of prototype foamy virus replication by modulating H3K9me3 marks and destabilizing the viral transactivator Tas

Fig. 6

A hypothetical model depicting Trim28 mediated degradation of Tas and the regulation of PFV replication by Trim28-mediated multi-function control. Trim28 is identified as being recruited to the 5′LTR promoter region of the PFV genome. Trim28 inhibits Tas-dependent transactivation activity of PFV LTR promoter though modulating H3K9me3 marks at LTR regions. Trim28 can interact with Tas to destabilizes of Tas via ubiquitin-proteasome pathway to inhibit PFV transcription and replication

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Retrovirology

ISSN: 1742-4690

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