Table 5 Compounds targeting binding site 4: apical binding site

Compound 1 [195]

I2, E53, L83, I104, A105, T107, T108, T110, Q114, G116, W117, T119, H120, N121, V126, G127, R132

N/A

N/A

6.1 µM^a

N/A

Compound 2 [195]

N/A

N/A

N/A

1.2 µM^a

N/A

Compound 3 [195]

N/A

N/A

N/A

1.4 µM^a

N/A

Compound 4 [195]

W80, M96, G98, W117, H120, P122, P123, I124, P125, I129, R132

N/A

N/A

1.2 µM^a

N/A

Compound 5 [195]

N/A

N/A

N/A

2.8 µM

> 80 µM

Compound 6 [195]

N/A

N/A

N/A

0.95 µM

57 µM