Table 1 Neutralization breadth and potency of four bnAbs with distinct gp120 epitope specificities against Indian HIV-1 subtype C
Sl. No | Viruses | IC50 (µg/ml) | |||
|---|---|---|---|---|---|
VRC01 | CAP256-VRC26.25 | PGDM1400 | PGT121 | ||
1 | VB51.J22 | 0.08 |  > 5 |  > 5 |  < 0.002 |
2 | VB52.J9 | 0.77 |  < 0.002 |  < 0.002 | 0.26 |
3 | VB52.J29 | 1.3 |  < 0.01 |  > 5 | 0.09 |
4 | VB52.J30 | 0.39 |  < 0.002 |  < 0.002 | 0.09 |
5 | VB95.J22 | 1.3 |  < 0.01 |  > 5 | 0.09 |
6 | VB96.J21 | 0.33 |  > 5 |  > 5 | 0.04 |
7 | VB96.J44 | 0.9 | 3.19 |  > 5 | 0.04 |
8 | VB97.J10 | 0.52 |  > 5 | 3.05 | 0.09 |
9 | VB97.J15 | 0.22 |  > 5 | 0.22 | 0.12 |
10 | VB98.J1 | 0.88 |  < 0.002 |  < 0.002 | 0.17 |
11 | VB105.J10 | 0.2 |  < 0.002 |  > 5 | 1.02 |
12 | VB106.J38 | 0.06 |  > 5 | 0.32 | 0.05 |
13 | 2.J9 | 0.37 |  < 0.002 | 0.01 |  > 5 |
14 | 3-J16 | 0.06 |  > 5 | 1.59 |  < 0.002 |
15 | 2–3.J7 | 0.08 |  < 0.002 | 0.01 |  > 5 |
16 | 2–3.J4 | 0.1 |  < 0.002 | 0.01 |  > 5 |
17 | 2–3.J17 | 0.09 |  < 0.002 | 0.01 |  > 5 |
18 | 2–5.J3 | 0.17 |  < 0.002 | 0.03 |  > 5 |
19 | 2–5.J11 | 0.08 |  < 0.002 | 0.39 |  > 5 |
20 | 3–3.J9 | 0.17 |  > 5 |  > 5 | 0.31 |
21 | 3–5.J25 | 0.11 |  > 5 |  > 5 | 0.01 |
22 | 3–5.J38 | 0.2 | 0.53 | 1.01 |  < 0.002 |
23 | 4.J2 | 0.05 |  < 0.002 |  < 0.002 | 2.14 |
24 | 4.J22 | 0.07 |  < 0.002 |  < 0.002 | 1.43 |
25 | 4–2.J45 | 0.15 |  < 0.002 | 0.22 | 0.03 |
26 | 4–2.J46b | 0.06 |  < 0.0046 |  < 0.002 | 0.23 |
27 | 4–2.J45b | 0.05 |  < 0.002 |  < 0.002 | 0.01 |
28 | 4–2.J42b | 0.06 |  < 0.002 |  < 0.002 | 0.23 |
29 | 4–2.J41 | 0.04 |  > 5 |  > 5 |  < 0.002 |
30 | 4–2.J47b | 0.07 | 0.89 | 0.07 | 2.87 |
31 | 5.J41 |  > 5 | 0.05 |  > 5 | 0.13 |
32 | 7.J16 |  < 0.002 |  < 0.002 | 0.01 | 0.06 |
33 | 7.J20 | 0.03 |  < 0.002 |  < 0.002 | 0.01 |
34 | LT1 07.J1 | 3.82 |  < 0.002 | 0.06 | 0.07 |
35 | LT1 07.J4 | 2.93 |  < 0.002 | 0.08 |  < 0.002 |
36 | LT1 07.J26 | 2.18 |  < 0.002 |  < 0.002 |  < 0.002 |
37 | 2–7.J1 | 0.6 |  < 0.002 |  > 5 |  > 5 |
38 | 11.J25 | 0.56 | 0.01 |  > 5 |  > 5 |
39 | 11.J28 | 0.89 | 3 |  > 5 |  > 5 |
40 | 11–3.J9 | 0.37 |  < 0.002 |  < 0.002 |  < 0.002 |
41 | 2–9.J20 | 0.56 |  < 0.002 | 0.1 | 0.01 |
42 | 5.4.J18 |  > 5 |  < 0.002 | 0.87 | 0.07 |
43 | LT1 09.J3 | 3.05 |  < 0.002 |  < 0.002 |  < 0.002 |
44 | LT1 09.J8 |  > 5 |  < 0.002 |  < 0.002 | 0.03 |
45 | 11–5.J12 | 0.06 |  < 0.002 |  < 0.002 |  < 0.002 |
46 | 2–11.J16 | 0.05 |  < 0.002 | 0.01 | 0.01 |
47 | 4–5.J5 | 0.07 |  < 0.002 | 0.04 | 2.16 |
48 | NISA-N20-J10 | 0.01 |  < 0.002 |  < 0.002 | 0.01 |
49 | NISA-N20.J14 | 0.8 |  < 0.002 |  < 0.002 | 0.04 |
50 | NISA-N101.J12 |  > 5 |  < 0.002 | 0.03 | 0.08 |
51 | NISA-N110.J16 | 0.26 | 0.4 |  > 5 | 0.41 |
52 | INDO SA NLR 29.J80 | 0.37 |  > 5 |  > 5 |  > 5 |
53 | INDO SA NLR 29.J11 | 0.02 |  > 5 | 0.13 |  > 5 |
54 | PG37009v2.eJ9 |  > 5 |  < 0.002 |  > 5 | 0.22 |
55 | PG37009v2.eJ38 | 0.06 |  < 0.002 |  < 0.002 | 1.82 |
56 | PG37009v2.eJ58 | 0.06 |  < 0.002 | 0.01 | 1.61 |
57 | PG37112v2.J5 |  > 5 | 0.02 |  > 5 | 0.02 |
58 | PG37112v2.J9 |  > 5 | 0.02 |  > 5 |  > 5 |
59 | PG37072.J12 | 0.48 |  > 5 |  > 5 |  > 5 |
60 | PG37072.J16 | 1.04 | 0.02 | 0.07 |  > 5 |
61 | PG37066.J1 |  > 5 | 0.01 | 0.04 |  > 5 |
62 | PG37081.J36 |  > 5 |  < 0.002 |  < 0.002 | 0.11 |
63 | PG37087.J39 | 0.06 |  > 5 |  > 5 |  > 5 |
64 | PG37087.J44 | 0.05 |  > 5 |  > 5 |  > 5 |
65 | PG37089.J17 | 0.62 | 0.02 | 0.12 |  > 5 |
66 | PG37089.J20 | 0.27 |  < 0.01 |  < 0.01 | 0.53 |
67 | PG37089.J83 | 0.26 |  < 0.01 |  < 0.01 | 0.97 |
68 | PG37091.J41 | 0.06 |  > 5 | > 5 | 1.79 |
69 | PG37080.J6A | 0.06 |  > 5 |  > 5 |  > 5 |
70 | PG37080v1.J17 | 0.14 |  > 5 |  > 5 |  > 5 |
71 | PG37080.J158 | 0.25 | 2.46 | 0.09 |  > 5 |
| Â | % resistant viruses | 12.68 | 23.94 | 35.21 | 29.58 |
| Â | Median IC50 | 0.24 | 0.0033 | 0.225 | 0.095 |