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Fig. 4 | Retrovirology

Fig. 4

From: Neutralization diversity of HIV-1 Indian subtype C envelopes obtained from cross sectional and followed up individuals against broadly neutralizing monoclonal antibodies having distinct gp120 specificities

Fig. 4

Predictive analysis of effect of bnAb combinations on neutralization breadth and potency of HIV-1 Indian clade C. a Cumulative coverage of the virus panel (a fraction between 0 & 1) of 98 clones reported in the present study and CATNAP database from India at various IC50 values for single mAbs and/or mAb combinations with a target Ab concentration of 5 µg/ml. Dashed curve in each of the plots indicates four bnAb combinations. All other combinations are depicted according to the given color codes. Vertical dashed lines in each plot indicate the expected final Ab concentration of four bnAb combination (pink line) and combination under assessment (black line). b Predicted geometric IC50 values against each bnAb/combination based on experimental IC50 values for viruses from India (N-98, left boxplot in each group) vs Viruses from Africa retrieved from CATNAP (N = 250, right boxplot in each group). Black lines in each plot indicate Median IC50 values. Statistical comparison within each group was performed with Mann–Whitney test

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Retrovirology

ISSN: 1742-4690

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