Fig. 5

Amino acid sequence analysis of HTLV and STLV orf-I proteins. Alignment of amino acid sequences of p12 from HTLV-1A prototype (NC-001436; J02029; AF033817), and other previously described p12 sequences for HTLV-1A, HTLV-1B, HTLV-1C and STLV-1 available on Genbank. A dash (–) indicates a gap in the amino acid alignment, an asterisk (*) represents a stop codon, and a period (.) represents amino acid similarity. Functional elements are indicated as follows: the proteolytic cleavage sites between positions 9 and 10, and between 29 and 30 are highlighted in blue. The calcineurin binding motif is highlighted in gray, the ubiquitylation site is highlighted in yellow, the four SH3 binding domains are outlined in red, and IL-2Rβ and γ binding domain is outlined in magenta. The multi-alignment was performed with the Mega7 program using default parameters