Fig. 6
From: Effect of transcription inhibition and generation of suppressive viral non-coding RNAs
A proposed model of the effect of F07#13 on binding to TAR-gag. The model is based on the notion that the ncRNAs (i.e. TAR-gag) are made from HIV-1 LTR and upon the introduction of F07#13, there is an increase in the copy number of TAR-gag due to non-processive Pol II transcription. The increased abundance of TAR-gag leads to the sequestration of ubiquitinated Tat, potentially through the TAR sequence. The presence of protein complexes with RNA can constitute newly synthesized “RNA machines”, which cause the repression of HIV-1 transcription through epigenetic modifications and potentially contribute to gene silencing and latency