Table 10 In vitro selections using INSTI resistant viruses
From: HIV drug resistance against strand transfer integrase inhibitors
Starting genotype | Drug selection | Genotype (week) | References |
|---|---|---|---|
E92Q | DTG | E92Q (8), E92Q/R263K (30) | |
E92Q | RAL | E92Q, L74M/E92Q (8) | [52] |
E92Q | EVG | E92Q (8) | [52] |
E138K | RAL | T66I/T97A/E138K/P142T/G163R (30) | [88] |
E138K | EVG | G70R/E138K/N155H/V249I/R263K (30) | [88] |
Y143C | RAL | Y143R, Y143R/G163R, E92Q/Y143R, G163R/E170A (8) | [52] |
Y143R | DTG | Y143R (8) | [52] |
Y143R | RAL | Y143R, L74M/Y143R, Y143R/N155H (8) | [52] |
Q148K | DTG | E138K/Q148K (8) | [52] |
Q148K | RAL | Q148K, E138K/Q148K (8) | [52] |
Q148K | EVG | Q148K, E138K/Q148K (8) | [52] |
Q148R | DTG | ND (30) | [57] |
Q148R | DTG | G140S/Q148R, G140S/Q148R/V201I, E138K/G140S/Q148R (8) | [52] |
Q148R | RAL | Q148R, G140S/Q148R, G140S/Q148R/V259I, L74M/G140S/Q148R (8) | [52] |
Q148R | EVG | Q148R, E138K/Q148R (8) | [52] |
Q148H | DTG | G140S/Q148H, T97A/G140S/Q148H, V75I/E138K/G140S/Q148H/M154I (8) | [52] |
Q148H | RAL | G140S/Q148H | [52] |
Q148H | EVG | G140S/Q148H | [52] |
G140S | DTG | V131I/V54I/Q148R/G140S (30) | [57] |
N155H | DTG | N155H (8), N155H/R263K (30) | |
N155H | RAL | N155H, G70R/N155H, N155H/G163R/D232N, S119R/N155H, P142T/N155H/G163R (8) | [52] |
N155H | EVG | N155H, N155H/S230K, N155H/D232N, N155H/E170K, G70R/V75I/N155H (8) | [52] |
R263K | RAL | R263K (30) | [88] |
R263K | EVG | M50I/T66I/R263K (30) | [88] |
G118R | DTG | T66I/G118R/E138K (25) | |
G118R | RAL | T66I/G118R/E138K (30) | [88] |
G118R | EVG | T66I/G118R/E157Q (30) | [88] |
H51Y | DTG | H51Y/R262K (25) | [89] |
H51Y | RAL | H51Y/G140S/Q148R (30) | [88] |
H51Y | EVG | H51Y/T66I/S147G/G163R/E170K/D232N (30) | [88] |
G140S/Q148R | DTG | K14R/H51Y/V54I/G140S/Q148R (30) | [57] |
E92Q/N155H | DTG | E92Q/N155H (30) | [57] |
E138K/R263K | RAL | H51N/T66I/T97A/S119R/E138K/Y143H/R263K (30) | [88] |
E138K/R263K | EVG | M50I/T66I/S119R/E138K/S147G/R263K (30) | [88] |
H51Y/G118R | DTG | H51Y/G118R (25) | [89] |
H51Y/G118R | RAL | H51Y/T66I/G118R (30) | [88] |
H51Y/G118R | EVG | H51Y/T66I/S147G/H171R/D232N (30) | [88] |
H51Y/R263K | DTG | H51Y/E138K/R263K (25) | [89] |
H51Y/R263K | RAL | E138K/Y143R/R263K (30) | [88] |
H51Y/R263K | EVG | V31I/H51Y/E92Q/R263K (30) | [88] |