From: Human Immunodeficiency Virus gag and protease: partners in resistance
Gag mutation | Associated with PI exposure | Associated with PI resistance | Associated with maturation inhibitor resistance | |
---|---|---|---|---|
in vivo | in vitro | |||
MA | Â | Â | Â | Â |
E12K | Â | Â | Â | |
G62R | Â | yes [61] | Â | Â |
L75R | Â | Â | Â | |
R76K | Â | yes [62] | Â | |
Y79F | Â | yes [62] | Â | |
T81A | Â | yes [62] | Â | |
K112E | Â | yes [64] | Â | Â |
CS MA/CA | Â | Â | Â | Â |
V128I/T/A/del | yes [64] | yes [64] | Â | |
Y132F | Â | Â | Â | |
CA | Â | Â | Â | Â |
M200I | Â | yes [64] | Â | Â |
H219Q/P | Â | Â | Â | |
CS CA/p2 | Â | Â | Â | Â |
A360V | yes [46] | Â | Â | Â |
V362I | Â | yes [68] | Â | |
L363M/F/C/N/Y | Â | yes [61] | Â | |
S368C/N | Â | Â | yes [69] | |
p2 | Â | Â | Â | Â |
Q369H | yes [54] | Â | Â | |
V370A/M/del | yes [54] | Â | Â | |
T371del | yes [77] | Â | Â | |
CS p2/NC | Â | Â | Â | Â |
S373P/Q/T | Â | Â | Â | |
A374P/S | yes [78] | Â | Â | Â |
T375N/S | Â | Â | Â | |
I376V | Â | Â | Â | |
G381S | yes [46] | Â | Â | Â |
NC | Â | Â | Â | Â |
I389T | yes [77] | Â | Â | Â |
V390A/D | Â | Â | Â | |
I401T/V | yes [77] | yes [64] | Â | Â |
R409K | Â | Â | Â | |
CS NC/p1 | Â | Â | Â | Â |
E428G | yes [66] | Â | Â | Â |
Q430R | Â | yes [44] | Â | Â |
A431V | Â | |||
K436E/R | yes [10] | Â | ||
I437T/V | Â | |||
CS p1/p6-gag | Â | Â | Â | Â |
L449F/P/V | yes [55] | Â | ||
S451T/G/R | Â | Â | Â | |
R452S/K | yes [87] | yes [55] | Â | |
P453A/L/T | Â | |||
p6-gag | Â | Â | Â | Â |
E468K | Â | yes [59] | Â | Â |
Q474L | yes [77] | Â | Â | Â |
A487S | yes [77] | Â | Â | Â |
P497L | yes [77] | Â | Â | Â |
p6-pol | Â | Â | Â | Â |
V484G/I/P/S | yes [88] | Â | Â | Â |
CS TFP/p6pol | Â | Â | Â | Â |
D437N | Â | Â | Â |