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Table 2 Antiviral activities of the BVM analog CV-8611 against the WT and mutant HIV-1 subtype C viruses

From: A single G10T polymorphism in HIV-1 subtype C Gag-SP1 regulates sensitivity to maturation inhibitors

Compound

IC50 (nM)

K3016 WT

2.55375 ± 0.699

K3016 SP1:G10T

 > 500 nM

IndieC1 WT

133.6145 ± 2.59

IndieC1 SP1:T10G

31.3055 ± 9.586

ZM247 WT

 > 500 nM

ZM247 SP1:T10G

116.9423 ± 6.893

  1. The IC50s represent the mean ± standard deviations from two independent experiments
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Retrovirology

ISSN: 1742-4690

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